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Immunohistochemical localization of transforming growth factor beta 2 and gene expression using real-time pcr in capsaicin-administered rat testis during puberty

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dc.contributor.author Gökhan, Nur
dc.contributor.author Nazlı, Mümtaz
dc.contributor.author Eliş Yıldız, Sevda
dc.date.accessioned 2015-02-26T13:15:25Z
dc.date.available 2015-02-26T13:15:25Z
dc.date.issued 2014
dc.identifier.citation Nur, G , Nazlı, M , Yıldız, S . (2015). Immunohistochemical localization of transforming growth factor beta 2 and gene expression using real-time PCR in capsaicin-administered rat testis during puberty. Turkish Journal of Veterinary and Animal Sciences, 38 (4), 377-382. DOI: 10.3906/vet-1302-16 en_US
dc.identifier.issn 1300-0128 en_US
dc.identifier.uri http://hdl.handle.net/11672/951 en_US
dc.description.abstract The objective of this study was to investigate the effects of capsaicin on the testis distribution of transforming growth factor beta 2 (TGFβ2) and gene expression using real-time PCR in pubescent rats. In this study, rats were divided into 3 groups: capsaicin (CAP), sham, and control. The CAP group was injected with 1 mg/kg doses of capsaicin (10% ethanol and 1% Tween in an 80% distilled water mixture) subcutaneously every day for a period of 1 week. The sham group was injected with a solution of 10% ethanol and 1% Tween in a mixture of 80% distilled water and nothing was injected in control rats. Regarding the histological appearance of testicular sections, the sham and control groups maintained the structure of connective tissue and seminiferous tubule, while in the CAP group, gaps among the tubule cells, invagination in the tubule cell wall, tubular integrity degradation, and breakdowns in the connective tissue were also observed. TGFβ2 immunoreactivity was observed in mature spermatids of all groups; moreover, immunoreactivities in the groups were similar in intensity. These results demonstrate that capsaicin, which is already known to affect gastrointestinal, cardiovascular, and respiratory systems, also interferes with the expression of TGFβ2 in rat testis. en_US
dc.description.sponsorship TÜBİTAK en_US
dc.language.iso eng en_US
dc.publisher Turkish Journal of Veterinary and Animal Sciences en_US
dc.relation.ispartofseries 38;377-382 en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Capsaicin en_US
dc.subject TGFβ2 en_US
dc.subject Testis en_US
dc.subject Real-time PCR en_US
dc.subject İmmunohistochemistry en_US
dc.title Immunohistochemical localization of transforming growth factor beta 2 and gene expression using real-time pcr in capsaicin-administered rat testis during puberty en_US
dc.type article en_US


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