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Evaluation of albendazole treatment on coagulation profile in sheep naturally infected with Dicrocoelium dentriticum

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dc.creator ERDOĞAN, Hasan
dc.creator GÜLTEKİN, Mehmet
dc.creator URAL, Kerem
dc.creator PARLATIR, Yasin
dc.creator AYAN, Adnan
dc.creator ERDOĞAN, Songul
dc.creator PAŞA, Serdar
dc.date 2019-06-30T00:00:00Z
dc.date.accessioned 2020-10-11T18:51:16Z
dc.date.available 2020-10-11T18:51:16Z
dc.identifier https://dergipark.org.tr/tr/pub/maeuvfd/issue/46573/523108
dc.identifier 10.24880/maeuvfd.523108
dc.identifier.uri https://hdl.handle.net/11672/3300
dc.description The aim of the present study was to evaluate the selected coagulation profile parameters in sheep naturally infected with Dicrocoeliumdentriticum and effects of albendazole treatment. For this reason, 34 merino sheep, aged between 1 and 3 years, naturally infected with Dicrocoeliumdentriticumwere enrolled in the present study. Plasma and stool samples were withdrawn from each animal before and 10 days after treatment and egg per gram feces were evaluated with Mc Master technique. Prothrombin time activated partial thromboplastin time and fibrinogen levels were determined by semiautomated coagulometer by using commercial test kits before and 10 days after treatment.Noticeable clinical recovery was detected in all animals after albendazole treatment. There were significant differences on Prothrombin time and fibrinogen levels a p value of (p<0.001) between treatment intervals. In conclusion, this is the first study for selected coagulation parameters before and after albendazole treatment for ovine patients naturally infected with Dicrocoeliumdentriticum. It should be mentioned that the treatment resulted in lower prothrombin time and fibrinogen values, suggesting that dicrocoeliasis might alter coagulation profile and possibly induce an acute phase response. Furthermore, the clinical relevance in ovine medicine and related results possibly interacting to human medicine has to be determined by future studies.
dc.format application/pdf
dc.language en
dc.publisher Mehmet Akif Ersoy University
dc.publisher Mehmet Akif Ersoy Üniversitesi
dc.relation https://dergipark.org.tr/tr/download/article-file/748475
dc.source Volume: 4, Issue: 1 8-13 en-US
dc.source 2148-6239
dc.source Veterinary Journal of Mehmet Akif Ersoy University
dc.subject Activated partial thromboplastin,anthelmintic,fibrinogen,liver fluke,prothrombin
dc.title Evaluation of albendazole treatment on coagulation profile in sheep naturally infected with Dicrocoelium dentriticum en-US
dc.type info:eu-repo/semantics/article


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