Immunohistochemical Determination of the Matrix Metalloproteinase-2 and -7 Expression in Transmissible Venereal Tumor in Dogs

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dc.creatorÖZMEN, Özlem; MEHMET AKIF ERSOY UNIVERSITY, FACULTY OF VETERINARY
dc.creatorOGUS, Ezgi; MEHMET AKIF ERSOY UNIVERSITY, FACULTY OF VETERINARY
dc.date2018-12-30T00:00:00Z
dc.date.accessioned2019-04-09T07:20:48Z
dc.date.available2019-04-09T07:20:48Z
dc.descriptionTransmissible venerealtumor (TVT) is a sexually transmitted, naturally occurring tumor of the caninefamily and often occurs in tropical and subtropical countries. The matrix metalloproteinases(MMPs) are endogenous proteases accountable for the degradation ofextracellular matrix (ECM) components, such as collagen and other proteins includingthe basement membrane. MMPs play a vital role in the tumor metastasis andangiogenesis. Both MMP-2 and -7 strongly associated with the invasion andmetastasis of different cancer types. This study aims to investigate the MMP-2and -7 expression in naturally occurring TVT in 20 dogs using immunohistochemicalmethods. Immunohistochemically, we observed increased MMP-2 and -7 expressions intumor cells. In addition, a positive correlation was determined between the tumorsize and immunoexpressions of the markers indicatingthat both MMP-2 and -7 participate in theTVT pathogenesis.
dc.formatapplication/pdf
dc.identifierhttp://dergipark.gov.tr/maeuvfd/issue/41984/481960
dc.identifier10.24880/maeuvfd.481960
dc.identifier.urihttp://hdl.handle.net/11672/2473
dc.languageen
dc.publisherMehmet Akif Ersoy University
dc.publisherMehmet Akif Ersoy Üniversitesi
dc.relationhttp://dergipark.gov.tr/download/article-file/614255
dc.sourceVolume: 3, Issue: 2 106-110
dc.source2458-9268
dc.source2148-6239
dc.subjectdog,pat
dc.titleImmunohistochemical Determination of the Matrix Metalloproteinase-2 and -7 Expression in Transmissible Venereal Tumor in Dogs
dc.typeinfo:eu-repo/semantics/article

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Veterinary Journal of Mehmet Akif Ersoy University