Investigation of antiproliferative effects of Hypericum perforatum oil on myeloma cells

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dc.creatorTUTUN, Soner
dc.creatorKAYA, Muhammet Mükerrem
dc.creatorUSLUER, Melike Sultan
dc.creatorTUTUN, Hidayet
dc.date2020-08-31T00:00:00Z
dc.date.accessioned2020-10-11T18:51:15Z
dc.date.available2020-10-11T18:51:15Z
dc.descriptionSt. Johns wort (Hypericum perforatum) is a medicinal plant that exhibits important biological activities exhibit important biological activities being antioxidant, anti-inflammatory, immunomodulatory and/or antitumour. The aim of this study was to investigate antiproliferative effect of H. perforatum oil purchased from a commercial vendor on mouse myeloma cells. The cells were treated with various concentration (10%, 5%, 2%, 1%, 0.5%, 0.25%, 0.2% and 0.1%) of dimethyl sulfoxide (DMSO) to determine the non-toxic concentration. The cells were treated with various concentrations (15.6-500 ppm) of the oil dissolved in DMSO to examine its antiproliferative activity. Non-toxic dose of DMSO was at the concentration of lower than 0.2%. No effect on the cell proliferation was observed in the applied concentration of the oil. In conclusion, the oil had no antiproliferative effect on Myeloma cells at these concentrations.
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dc.identifierhttps://dergipark.org.tr/tr/pub/maeuvfd/issue/55084/728975
dc.identifier10.24880/maeuvfd.728975
dc.identifier.urihttps://hdl.handle.net/11672/3298
dc.languageen
dc.publisherMehmet Akif Ersoy University
dc.publisherMehmet Akif Ersoy Üniversitesi
dc.relationhttps://dergipark.org.tr/tr/download/article-file/1265738
dc.sourceVolume: 5, Issue: 2 79-82en-US
dc.source2148-6239
dc.sourceVeterinary Journal of Mehmet Akif Ersoy University
dc.subjectAntiproliferative activity,Hypericum perforatum,Myeloma cells
dc.titleInvestigation of antiproliferative effects of Hypericum perforatum oil on myeloma cellsen-US
dc.typeinfo:eu-repo/semantics/article

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Veterinary Journal of Mehmet Akif Ersoy University