Investigation of antiproliferative effects of Hypericum perforatum oil on myeloma cells

TUTUN, Soner; KAYA, Muhammet Mükerrem; USLUER, Melike Sultan; TUTUN, Hidayet

Investigation of antiproliferative effects of Hypericum perforatum oil on myeloma cells

Authors

TUTUN, Soner

KAYA, Muhammet Mükerrem

USLUER, Melike Sultan

TUTUN, Hidayet

Publisher

Mehmet Akif Ersoy University
Mehmet Akif Ersoy Üniversitesi

Description

St. Johns wort (Hypericum perforatum) is a medicinal plant that exhibits important biological activities exhibit important biological activities being antioxidant, anti-inflammatory, immunomodulatory and/or antitumour. The aim of this study was to investigate antiproliferative effect of H. perforatum oil purchased from a commercial vendor on mouse myeloma cells. The cells were treated with various concentration (10%, 5%, 2%, 1%, 0.5%, 0.25%, 0.2% and 0.1%) of dimethyl sulfoxide (DMSO) to determine the non-toxic concentration. The cells were treated with various concentrations (15.6-500 ppm) of the oil dissolved in DMSO to examine its antiproliferative activity. Non-toxic dose of DMSO was at the concentration of lower than 0.2%. No effect on the cell proliferation was observed in the applied concentration of the oil. In conclusion, the oil had no antiproliferative effect on Myeloma cells at these concentrations.