New chroman-4-one/thiochroman-4-one derivatives as potential anticancer agents

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dc.contributor.authorDemirayak, Şeref
dc.contributor.authorYurttaş, Leyla
dc.contributor.authorGündoğdu Karaburun, Nalan
dc.contributor.authorKaraburun, Ahmet Cağrı
dc.contributor.authorKayağil, İsmail
dc.contributor.departmentMehmet Akif Ersoy Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü, Organik Kimya Anabilim Dalıen_US
dc.date.accessioned2017-12-22T07:57:10Z
dc.date.available2017-12-22T07:57:10Z
dc.date.issued2017-11
dc.description.abstractThe synthesis of 3-[3/4-(2-aryl-2-oxoethoxy)arylidene]chroman/thiochroman-4-one derivatives (1–34) and evaluation of their anticancer activities were aimed in this work. Final compounds were obtained in multistep synthesis reactions using phenol/thiophenol derivatives as starting materials. For anticancer activity evaluation, all compounds were offered to National Cancer Institute (NCI), USA and selected ones were tested against sixty human tumor cell lines derived from nine neoplastic diseases. The activity results were evaluated according to the drug screening protocol of the institute. Compounds containing thiochromanone skeleton exhibited higher anticancer activity.en_US
dc.identifier.citationDemirayak, S., Yurttas, L., Gundogdu-Karaburun, N., Karaburun, A. C., & Kayagil, I. (2017). New chroman-4-one/thiochroman-4-one derivatives as potential anticancer agents. Saudi Pharmaceutical Journal, 25(7), 1063–1072. https://doi.org/10.1016/J.JSPS.2017.04.040en_US
dc.identifier.endpage1072en_US
dc.identifier.issue7en_US
dc.identifier.startpage1063en_US
dc.identifier.urihttp://hdl.handle.net/11672/965en_US
dc.identifier.volume25en_US
dc.language.isoengen_US
dc.publisherKing Saud Universityen_US
dc.relation.journalSaudi Pharmaceutical Journalen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChromanoneen_US
dc.subjectThiochromanoneen_US
dc.subjectBenzopyranoneen_US
dc.subjectBenzothiopyranoneen_US
dc.subjectFlavoneen_US
dc.subjectAlphaen_US
dc.subjectBeta-Unsaturated Carbonylen_US
dc.subjectAnticancer Activityen_US
dc.titleNew chroman-4-one/thiochroman-4-one derivatives as potential anticancer agentsen_US
dc.typearticleen_US

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